You describe how bitterly you regret the inefficacy of your prayers. Beware: to wish for consolation or revelation in prayer is a sure sign of pride. Pray humbly, in perfect simplicity, seeking salvation only through forgiveness, & having faith that God will extend to you His mercy - as He did to the publican.
Keep your conscience keen and bright, and refrain from hankering after, or expecting, consolation. Leave that to God. He knows when, where, and how to give it to you.
The most important thing during illness is to offer to God patience and thanksgiving for His merciful visitations. Sickness purifies sins and gives one time to meditate on the past.
You ask for some way of completely eradicating irritability. The inclination to irritability is given us to use against sin, and we were never meant to use it against our fellow men. When we do, we act contrary to our true nature.
If the soul is vigilant and withdraws from all distraction and abandons its own will, then the spirit of God invades it and it can conceive because it is free to do so.
When God, using our conscience, calls us to righteousness and yet our self-will opposes Him, He respects our freedom and lets our own will be done; but then, alas, our minds grow dull, our will slack, and we commit iniquities without number. On the other hand, the fruits of the spirit are soon granted to them who follow the commandments of Christ our Lord.
The lives of men are subject to drastic changes. These changes are gradual at times; at others, lightning quick. But even those of us who enjoy long years of opulence and fame can find no consolation, no gladness, unless our heart is illumined by the steady light of peace. It is this peace that we must seek, it is for this peace that we should pray. The peace that our Lord gave to His disciples and to all those who really have faith in him.
Faith is truly a gift, gained for us through Christ's advent. But this does not abolish our freedom or responsibility. God desires of us not only faith but action too.
Behold, this is the true and the Christian humility. In this you will be able to achieve victory over every vice, by attributing to God rather than to yourself the fact that you have won.
Never allow yourself boldly to judge your neighbor; judge and condemn no one, ... rather have compassion and pity for him, but let his example be a lesson in humility to you; realizing that you too are extremely weak and as easily moved to sin as dust on the road, say to yourself: 'He fell today, but tomorrow I shall fall.'