Pray simply. Do not expect to find in your heart any remarkable gift of prayer. Consider yourself unworthy of it. Then you will find peace. Use the empty cold dryness of your prayer as food for your humility. Repeat constantly: I am not worthy; Lord, I am not worthy! But say it calmly; without agitation.
We know there are Angels and Archangels, Thrones, Dominions, Princedoms, Powers, Splendors, Ascents, Intelligent Powers or Intelligences, pure natures and unalloyed, immovable to evil, or scarcely movable; ever circling in chorus round the First Cause (or how should we sing their praises?) illuminated thence with the purest Illumination, or in one degree or another, proportionally to their nature and rank...so conformed to beauty and molded that they become secondary Lights, and can enlighten others by the overflowings and largesse of the First Light. Ministrants of God's Will, strong with both inborn and imparted strength, traversing all space, readily present to all at any place through their zeal for ministry and the agility of their nature...
The abstinent withdraws from gluttony, the uncovetous from covetousness, the silent from wordiness, the pure from attachment to sensory pleasures, the chaste from fornication, he who is content with what he has from love of money, the meek from agitation (anger), the humble from vanity, the obedient from objection, he who is honest with himself from hypocrisy; equally, he who prays withdraws from despair, the willing pauper from acquisitiveness, he who professes his faith from denying it, the martyr from idolatry – so you see that each virtue, performed even unto death, is nothing but withdrawal from sin; and withdrawal from sin is a natural action, not an action which could be rewarded by the kingdom.
If you wish to be saved and 'to come unto the knowledge of the truth' (I Tim. 2:4), endeavor always to transcend sensible things, and through hope alone to cleave to God. Then you will find principalities and powers fighting against you (Eph. 6:12), deflecting you against your will and provoking you to sin. But if you prevail over them through prayer and maintain your hope, you will receive God's grace, and this will deliver you...
You ask for some way of completely eradicating irritability. The inclination to irritability is given us to use against sin, and we were never meant to use it against our fellow men. When we do, we act contrary to our true nature.
Most people desire and seek after prosperity in this life, and they strive to avoid sorrows. While that seems very good and pleasant, constant prosperity and good fortune do a person harm. He falls into a variety of passions and sins, and angers the Lord, while those who live a life of sorrow come closer to the Lord and more readily attain unto salvation, for the Lord called the life of happiness the broad path. The wide gates and the broad way lead to destruction, and many there be who take that way (Matthew 7:13). It is the narrow way and the strait gate which lead to life eternal, and few there be who find it (Matthew 7:14). Thus, according to His love for us, seeing the possible benefit [of sorrows] to those who are worthy, the Lord moves many off the broad road and puts them on the narrow, sorrowful path, so that in [their] patient endurance of sickness and sorrow, He might effect their salvation and grant them life eternal.
The most important thing during illness is to offer to God patience and thanksgiving for His merciful visitations. Sickness purifies sins and gives one time to meditate on the past.
According to the teaching of the Fathers, any impression which, touching the heart, fills it with a great irritation, must come from the region of passions. Therefore impulses which spring from the heart should not be followed at once, but only after careful examination and fervent prayer. God preserve us from a blind heart! It is well known that passions do blind the heart and screen the shining sun of the mind that we should all strive to gaze at.
Dr. George Bebis writes that 'In one of his letters, St. Basil [the Great] explicitly writes that he accepts the intercession of the apostles, prophets and martyrs, and he seeks their prayers to God. (Letter 360) Then, speaking about the Forty Martyrs, who suffered martyrdom for Christ, he emphasizes that they are common friends of the human race, strong ambassadors and collaborators in fervent prayers. (Chapter 8) St. Gregory of Nyssa asks St. Theodore the Martyr... to fervently pray to our Common King, our God, for the country and the people (Encomium to Martyr Theodore).;
Bear this in mind: the Christian life is an unending spiritual fight. The wily enemy cleverly uses snares and arrows without number. Before some of us he spreads the lure of worldliness, the outer pride of pomp and circumstance, the cruder lusts-the lusts of the flesh. But those of us who are not attracted by any of this he leads up on to the peaks of subtler prides. Having got us there-to the high country of self-esteem-he causes a dark mist, the mist of the subtlest prides, to enshroud our intellect. Then he leads us, his blinded slaves, away from God, without our even suspecting it. Mark this too: it is not very hard for the simple sinner to come to hate his foul life and, leaving it, to fling himself on the mercy of God; but it is very hard for the subtler sinner-the self-sufficient one-to let a ray of divine love pierce the leather jacket of his self-righteousness... Humility is the only weapon that wards off all attacks, but it is difficult to fashion, and the art of using it is often misunderstood, particularly by those who lead an active, worldly life.
A life lived in the world can be as good, in the eyes of God, as one spent in a monastery. It is indeed only the keeping of God's commandments, love of all, and a true sense of humility that matter, wherever we are.
You describe how bitterly you regret the inefficacy of your prayers. Beware: to wish for consolation or revelation in prayer is a sure sign of pride. Pray humbly, in perfect simplicity, seeking salvation only through forgiveness, & having faith that God will extend to you His mercy - as He did to the publican.