In this time of fasting and prayer, brethren, let us with all our hearts forgive anything or imaginary we have against anyone. May we all devote ourselves to love, and let us consider one another as an incentive to love and good works, speaking in defense of one another, having good thoughts and dispositions within us before God and men. In this way our fasting will be laudable and blameless, and our requests to God while we fast we will readily received. We shall rightly call upon Him as our Father by grace and we can boldly say to Him, 'Father, forgive us our debts, as we forgive our debtors' (Matt. 6:12),
We ought not to grieve or become irritated at anything because, by frequent vexation and irritability, we form the morally and physically very injurious habit of irritability, whilst by bearing opposition with equanimity we form the good and useful habit of enduring everything calmly and patiently.
According to the teachings of the Holy Fathers, in order to destroy insensibility man needs a constant, patient, uninterrupted activity against insensibility; he needs a constant, pious, and attentive life.
Now you become angry and fainthearted and grieved, thinking that the heavenly Father is slow in answering. But I tell you that this will also happen as you desire—it will definitely happen—but first it takes prayer with all your soul, and then you must wait. And when you have forgotten your request and have ceased asking for it, it will come to you as a reward for your patience and endurance. When you reach the verge of despair while praying and seeking, then the fulfillment of your request is near. Christ wants to heal some hidden passion within you, and this is why He delays in granting your request. If you obtain it sooner, when you demand it, your passion remains uncured within you. If you wait, you obtain your request and the cure of the passion. And then you rejoice exceedingly and give warm thanks to God Who arranges all things in wisdom and does everything for our benefit.
You ask for some way of completely eradicating irritability. The inclination to irritability is given us to use against sin, and we were never meant to use it against our fellow men. When we do, we act contrary to our true nature.