According to the teachings of the Holy Fathers, in order to destroy insensibility man needs a constant, patient, uninterrupted activity against insensibility; he needs a constant, pious, and attentive life.
Those who have acquired genuine prayer experience an ineffable poverty of the spirit when they stand before the Lord, glorify and praise Him, confess to Him, or present to Him their entreaties. They feel as if they had turned to nothing, as if they did not exist. That is natural. For when he who is in prayer experiences the fullness of the divine presence, of Life Itself, of Life abundant and unfathomable, then his own life strikes him as a tiny drop in comparison to the boundless ocean. That is what the righteous and long-suffering Job felt as he attained the height of spiritual perfection. He felt himself to be dust and ashes; he felt that he was melting and vanishing as does snow when struck by the sun's burning rays (Job 42:6).
We must accomplish the course of our earthly pilgrimage with the greatest attention and watchfulness over ourselves, unceasingly calling upon God in prayer for help.
The soul of all practices in the Lord is vigilance. Without vigilance, all these practices are fruitless. He who is desirous of saving himself must so establish himself that he might remain continuously vigilant toward himself, not only in solitude, but also under conditions of distraction, into which he is sometimes unwillingly drawn by circumstances.
Sear your loins by abstaining from food, and prove your heart by controlling your speech, and you will succeed in bringing the desiring and incensive powers of your soul into the service of what is noble and good.