When God, using our conscience, calls us to righteousness and yet our self-will opposes Him, He respects our freedom and lets our own will be done; but then, alas, our minds grow dull, our will slack, and we commit iniquities without number. On the other hand, the fruits of the spirit are soon granted to them who follow the commandments of Christ our Lord.
It is no small struggle to be freed from self-esteem. Such freedom is to be attained by the inner practice of the virtues and by more frequent prayer; and the sign that you have attained it is that you no longer harbor rancor against anybody who abuses or has abused you.
Trials are sent to some so as to take away past sins, to others so as to eradicate sins now being committed, and to yet others so as to forestall sins which may be committed in the future. These are distinct from the trials that arise in order to test men in the way Job was tested.
If we cut off the causes of the passions for only a short while, and occupy ourselves with spiritual contemplation without making it our sole and constant concern, we easily revert to the passions of the flesh, gaining nothing from our labor but theoretical knowledge coupled with conceit. The result is a gradual darkening of this knowledge itself and a complete turning of the intellect towards material things.
Be glad and rejoice that you were granted to be pious Orthodox Christians. Likewise again cry and mourn for the impious and unbelievers who walk in darkness, in the hands of the devil.
If someone is judged worthy to receive the gift of knowledge but allows his heart to be full of bitterness or rancor or aversion to another, it is as if he had been struck in the eye by a thornbush. That is why knowledge is no good without charity.
It is vain that some unenlightened people seek the greatest evil for man somewhere else, rather than in sin. Some consider disease to be the greatest evil, others - poverty, and others - death. But neither disease, nor poverty, nor death, nor any other earthly disaster can be such a great evil for us as sin is. These earthly misfortunes do not separate us from God if we are seeking Him sincerely, but, on the contrary, they bring us closer to Him.
You describe how bitterly you regret the inefficacy of your prayers. Beware: to wish for consolation or revelation in prayer is a sure sign of pride. Pray humbly, in perfect simplicity, seeking salvation only through forgiveness, & having faith that God will extend to you His mercy - as He did to the publican.
Do not think that even here any one of us constantly enjoys consolation. No: here, as everywhere, flesh and mind are at war; here as everywhere, there is falling into pride and purification through humbling: here, as everywhere, we long for consolations but must learn to carry a weighty cross. This cross tests our love. Can we, do we love God even under the weight of the most bitter adversities?
The enemy constantly endeavors to awaken in the abyss of the human heart a great turmoil about trifles. This is one of his tricks to blind our soul to the sun of truth, Christ our Lord, hidden in the heart's core of every one of our neighbors.
The most important thing during illness is to offer to God patience and thanksgiving for His merciful visitations. Sickness purifies sins and gives one time to meditate on the past.
Wherever we are and whatever our circumstances, the enemy always tries to prevent us from actively responding to the call. Pray for help. For help that you may never fail to respond. And beware lest, having received help and having done the right deed because of it, you should grow proud and acquire the habit of condemning others, in the secret chambers of your heart. Beware! For this would make all the fruits of your good works wither.
Remember always that, once we have decided consciously to strive after righteousness, we cannot escape catastrophes and sorrows, no matter where we are.