You ask for some way of completely eradicating irritability. The inclination to irritability is given us to use against sin, and we were never meant to use it against our fellow men. When we do, we act contrary to our true nature.
Ponder the truth of Christian marriage: man and wife are one flesh! Does it not follow that they must share all their possessions? And yet you two haggle over this property! And why? Because of words!
Comprising one flesh, [the couple] also has a single soul, and their mutual love awakens in them a zeal for piety. For the state of wedlock does not estrange us from God, but rather ties us more closely to Him, for it brings forth a greater impetus to turn to Him. Even under a light breeze, a small boat moves forward…., a light breeze will not move a great ship.... Thus, those not burdened with secular concerns have less need of help from Almighty God, but one who has responsibilities, who looks after his beloved spouse, his estate and his children, traverses a broader sea of life, and has greater need of God’s help. In return [for that help], he himself comes to love God even more.
Do not think that even here any one of us constantly enjoys consolation. No: here, as everywhere, flesh and mind are at war; here as everywhere, there is falling into pride and purification through humbling: here, as everywhere, we long for consolations but must learn to carry a weighty cross. This cross tests our love. Can we, do we love God even under the weight of the most bitter adversities?
But if you give a strong body rest and ease and idleness, all the passions dwelling in the soul are intensified. Then, even if the soul has a great desire for good, even the very thought of the good that is desired will be taken from you.
Most people desire and seek after prosperity in this life, and they strive to avoid sorrows. While that seems very good and pleasant, constant prosperity and good fortune do a person harm. He falls into a variety of passions and sins, and angers the Lord, while those who live a life of sorrow come closer to the Lord and more readily attain unto salvation, for the Lord called the life of happiness the broad path. The wide gates and the broad way lead to destruction, and many there be who take that way (Matthew 7:13). It is the narrow way and the strait gate which lead to life eternal, and few there be who find it (Matthew 7:14). Thus, according to His love for us, seeing the possible benefit [of sorrows] to those who are worthy, the Lord moves many off the broad road and puts them on the narrow, sorrowful path, so that in [their] patient endurance of sickness and sorrow, He might effect their salvation and grant them life eternal.
You describe how bitterly you regret the inefficacy of your prayers. Beware: to wish for consolation or revelation in prayer is a sure sign of pride. Pray humbly, in perfect simplicity, seeking salvation only through forgiveness, & having faith that God will extend to you His mercy - as He did to the publican.
Not every man is wakened to wonder by what is said spiritually and has great power concealed in it. A word concerning virtue has need of a heart unbusied with the earth and its converse.