For those who bear them with faith, misfortunes serve to correct their sins, to exercise and test them, to lead them to abandon the wretchedness of this life, and to encourage them to long fervently and seek constantly for everlasting adoption as sons and redemption, the truly new life and blessedness.
You ask for some way of completely eradicating irritability. The inclination to irritability is given us to use against sin, and we were never meant to use it against our fellow men. When we do, we act contrary to our true nature.
Since the angels and souls are incorporeal beings, they are not in a particular place, yet neither are they everywhere. They do not sustain all things, but themselves depend on Him Who sustains them. Hence they, too, are in Him Who sustains and embraces all things, and they are appropriately delimited by Him. The soul, since it sustains the body with which it is created, is everywhere in the body, although not in the sense of being located in a place or encompassed; but it itself sustains, encompasses and quickens the body, by virtue of the fact that it is in God's image.
If the soul is vigilant and withdraws from all distraction and abandons its own will, then the spirit of God invades it and it can conceive because it is free to do so.
Do not love the world, all the deceit of the world, for it passes by quickly along with all its pleasures. Only he who does the will of God remains unto the ages.
The most important thing during illness is to offer to God patience and thanksgiving for His merciful visitations. Sickness purifies sins and gives one time to meditate on the past.
He who seeks grace from God must, above all, endure temptations and afflictions no matter how they come. Otherwise, if he becomes indignant and doesn't show enough patience during temptation, neither will grace manifest itself, nor will his virtue be perfected or will he be counted worthy of any spiritual gift.
God always helps. He always comes in time, but patience is necessary. He hears us immediately when we cry out to Him, but not in accordance with our own way of thinking.